Aflatoxin exposure in utero causes growth faltering in Gambian infants
نویسندگان
چکیده
منابع مشابه
Aflatoxin exposure in utero causes growth faltering in Gambian infants.
BACKGROUND Growth faltering in West African children has previously been associated with dietary exposure to aflatoxins, particularly upon weaning. However, in animal studies in utero exposure to low levels of aflatoxin also results in growth faltering. OBJECTIVE This study investigated the effect of in utero aflatoxin exposure on infant growth in the first year of life in The Gambia. METHO...
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BACKGROUND Growth faltering during infancy is a characteristic of life in developing countries. Previous studies have shown that small-intestine mucosal enteropathy, accompanied by endotoxemia and a persistent systemic inflammatory response, accounts for up to 64% of the growth faltering in Gambian infants. OBJECTIVE The objective was to test whether glutamine, with its putative trophic effec...
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BACKGROUND Growth faltering remains common in children in sub-Saharan Africa and is associated with substantial morbidity and mortality. Due to a very slow decline in the prevalence of stunting, the total number of children with stunting continues to rise in sub-Saharan Africa. Identification of effective interventions remains a challenge. METHODS We analysed the effect of 36 years of intensi...
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متن کاملExposure to aflatoxin B1 in utero is associated with DNA methylation in white blood cells of infants in The Gambia.
BACKGROUND Exposure to environmental toxins during embryonic development may lead to epigenetic changes that influence disease risk in later life. Aflatoxin is a contaminant of staple foods in sub-Saharan Africa, is a known human liver carcinogen and has been associated with stunting in infants. METHODS We have measured aflatoxin exposure in 115 pregnant women in The Gambia and examined the D...
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ژورنال
عنوان ژورنال: International Journal of Epidemiology
سال: 2007
ISSN: 0300-5771,1464-3685
DOI: 10.1093/ije/dym122